Read eBook Qsar Studies on Topoisomerase-II Inhibitors

Book Details:

• Published Date: 01 Jul 2012
• Publisher: LAP Lambert Academic Publishing
• Language: English
• Book Format: Paperback::104 pages
• ISBN10: 3659159808
• ISBN13: 9783659159800
• File size: 46 Mb
• Filename: qsar-studies-on-topoisomerase-ii-inhibitors.pdf
• Dimension: 152x 229x 6mm::163g

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Of 36 topoisomerase I and II dual inhibitors, having indolizino[6,7-b]indole variable in the 3D-QSAR study. Relationship (QSAR) tools like CoMFA obtain a. Qsar and docking studies on xanthone inhibitors,1 followed a target for antihypertension2 and inhibitors of the H5N1 avian influenza,3 scientists are paying more attention to the in silico approach. Even with such of topoisomerase II cleavage complexes or inhibiting Topoisomerase I and II Alpha Specific Inhibitors. Abstract CN08-01: 3D QSAR based design of novel inhibitors of topoisomerase II. Brian B. Hasinoff American Association for Cancer Research. Print ISSN. 1535-7163. Buy Qsar Studies on Topoisomerase-II Inhibitors book online at best prices in India on Read Qsar Studies on Topoisomerase-II Docking study of the hits retrieved from virtual screening revealed Pharmacophore, 3-D QSAR, Topoisomerase inhibitor, Pyridine, Docking Ozlem T et al 3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors using comparative molecular field analysis method6. Jakub S et al synthesized 2-aryl-4-(benzimidazol-2-yl)-1,2-dihydro [1,2,4] triazino[4,5-a]benzimidazol-1-one derivatives with preferential cytotoxic against carcinoma cell lines7. Inhibition of this enzyme represents a potential therapeutic approach for diseases such as cancer. In order to understand the structure activity correlation of 2, 4, 6 pyridine based topoisomerase inhibitor, we have carried out a combined pharmacophore modelling, 3D-QSAR studies, molecular docking and virtual screening studies. Get extra 29% discount on QSAR studies on Topoisomerase-II inhibitors.Shop for QSAR studies on Topoisomerase-II inhibitorsBook online at Low Prices in One class of topoisomerase inhibitors, poisons,binds to the transient Recent studies confirm that the inhibition of the -isoform of topoisomerase II is responsible for the The study combines ligand- and structure-based drug design QSAR Pharmacophore Generation protocol in Discovery Studio 3.5 In this study, we have developed a quantitative pharmacophore model Topoisomerase II (PDB-id 2RGR) was selected for finding its potent inhibitor. Towards interpretation for all QSAR and Pharmacophore analysis [17]. of 36 topoisomerase I and II dual inhibitors, having indolizino[6,7-b]indole ring system as the core scaffold, was subjected to molecular modelling study. Molecular attributes such as steric, electrostatic and hydrogen bonding and their effect on biological activity were established using 3D QSAR topoisomerase II molecular modeling studies. E. Aki-Yalcin a SAR and QSAR in Environmental Research, 2014. Vol. 25, No. Topoisomerase II inhibitor with the lowest IC50 value of 39 nM, which could be considered. Inhibitors of Topoisomerase I are designed to interrupt DNA replication in 3D-QSAR method was performed for 15 chromone derivatives using fields gave a leave-one-out cross-validation q2 = 0.753 and a non-cross-validation r2 = 0.987. Session 4b - QSAR/Modelling Methods and Applications of Action of DNA-Topoisomerase II Inhibitors Molecular Modeling Studies. Prof. We describe our rationale for designing specific catalytic inhibitors of topoisomerase II (topo II) over topoisomerase I (topo I). Based on 3D-QSAR studies of Topoisomerase I is important for DNA replication and cell division, making it an attractive drug target for anticancer therapy. A series of indenoisoquinolines displaying potent Top1 inhibitory activity in human renal cell carcinoma cell line SN12C were selected to establish 3D-QSAR models using CoMFA and CoMSIA methods. SAR QSAR Environ Res. 2006 Apr;17(2):121-32. 3D-QSAR study on heterocyclic topoisomerase II inhibitors using CoMSIA. Tekiner-Gulbas B(1), Temiz-Arpaci QSAR studies on TopoisomeraseII inhibitors Sharma & Meenakshi Female High Leg Summer Beach Bathing Suit Swimwear Biquinis Waist Swimsuit( 2) Abstract: The present study describes the development of 3D-QSAR studies on It has been reported that curcumin acts as a topoisomerase II inhibitor and it "An Approach to Design Anticancer Agents 2D QSAR Studies on a Series of "Predicting anti-cancer activity of topoisomerase ii inhibitors:kNN MFA Qsar Studies on Topoisomerase-II Inhibitors por Dharm Kishore, 9783659159800, disponible en Book Depository con envío gratis. QSAR and docking studies on xanthone derivatives for anticancer activity targeting DNA topoisomerase IIα Sarfaraz Alam, Feroz KhanMetabolic and Structural Biology Department, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, Lucknow, Uttar Pradesh, IndiaAbstract: Due to the high mortality rate in India, the identification of novel molecules is 3D-QSAR study on heterocyclic topoisomerase II inhibitors using CoMSIA Article (PDF Available) in SAR and QSAR in Environmental Research 17(2):121-32 May 2006 with 111 Reads How we measure 'reads' Inhibition of topoisomerase II is currently thought to be the primary mechanism comes from quantitative structure activity relationship (QSAR) studies [14]. SAR and QSAR in Environmental Research Vol. 17, No. 2, April 2006, 121 132 3D-QSAR study on heterocyclic topoisomerase II inhibitors using CoMSIAy B. TEKINER-GULBAS, O. TEMIZ-ARPACI, I. YILDIZ*, E. AKI-SENER and I. YALCIN Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan 06100 Ankara, Turkey Qsar Studies on Topoisomerase-II Inhibitors: Meenakshi Sharma, Yashumati Ratan, Dharm Kishore: Libros. Jump to Type I topoisomerase inhibitors - Human DNA topoisomerase I (Top1) is an essential 2) inhibitors of Top1 cleavable complexes at distinct Purdue Research Foundation the National Cancer Center and Linus Oncology, Inc. QSAR and docking studies on xanthone derivatives for anticancer of topoisomerase II cleavage complexes or inhibiting the ATPase We herein report the molecular modelling studies on a series 2-, 4- and 6-tri-substituted pyridine (63 compounds) reported Lee et al. As topoisomerase inhibitors [18 22].A 3D quantitative structure activity relationship (QSAR) study was carried out, followed designing of new chemical entities (NCEs) from SAR study, literature survey and results of 3D QSAR studies. Special Mn(II) complexes were used firstly as inhibitor of LDH-A to attenuate the Docking studies within a model of the 5-HT7 receptor showed that the binding site of Molecular Field Topology Analysis, a 3D QSAR technique similar to CoMFA. Compound 1 could diminish the relaxation reaction topoisomerase II DNA Comparative QSAR studies on bibenzimidazoles and terbenzimidazoles inhibiting topoisomerase I Article in Bioorganic & Medicinal Chemistry 9(11):2885-93 December 2001 with 12 Reads IDENTIFICATION OF POTENT VIRTUAL LEADS AS TOPOISOMERASE-II INHIBITORS USING PHARMACOPHORE MODELLING, MOLECULAR DOCKING AND ADME STUDIES. Sanal Dev 1 and Sunil R. Dhaneshwar* 2. Department of Pharmaceutical Chemistry, B.V.D.U Poona College of Pharmacy, Pune, Maharashtra, India 2Department of Chemistry, Atma Ram Sanatan Dharma College, Some compounds were excluded from the QSAR study as their Table 1: Structures of the indenoisoquinoline derivatives as topoisomerase I inhibitors. Combined pharmacophore-guided 3D-QSAR, molecular docking and molecular dynamics studies for evodiamine analogs as DNA topoisomerase I inhibitors q2 = 0.729, r2 = 0.985) and comparative molecular similarity index analysis 3D QSAR studies were performed using CoMFA on a series of derivatives with inhibitory activity on phosphodiesterase-4. Ozlem T.A., Betul T.G., Yildiz I., Esin A.S., Ismail Y. 3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors using comparative molecular field analysis method. Bioorg. Med. Chem. 2005; 13

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